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Testosterone Replacement Therapy is gaining popularity with many advocates and detractors. Lucas and Brion explore the evolutionary basis for testosterone and how that can inform your choice on whether to get on TRT Notes: Testosterone prescribing in the United States, 2002-2016: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396809/ Danish Study on Lowering T levels: https://academic.oup.com/jcem/article/92/12/4696/2597312#52560365 The He Hormone, 2000 New York Times: https://www.nytimes.com/2000/04/02/magazine/the-he-hormone.html Testicle Shrinkage: https://www.thebodywellusa.com/will-taking-testosterone-make-testicles-shrink/ Testosterone Therapy and anabolic steroids: https://thinksteroids.com/steroid-profiles/testosterone/ TRT shuts down production of Pregnenolone and other upstream metabolites: https://www.sciencedirect.com/science/article/pii/0022473185902572?via%3Dihub Supplementing Pregnenolone: https://www.testosteronewisdom.com/pregnenolone-what-you-need-to-know-about-this-precursor-hormone/