Rebel Cast

REBEL Core Cast 145.0: Understanding QTc Prolongation: Causes, Risks, and Management

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🧭 REBEL Rundown 📌 Key Points 🫀 Prolonged QTc raises risk of torsades de pointes ⏱️ Correct for heart rate: QTc > 440 ms (men) or > 460 ms (women); > 500 ms = high TdP risk.💊 Common culprits: Methadone, ondansetron, macrolides, fluoroquinolones, antipsychotics.🧪 Prevention: Check & replete K, Mg, Ca and avoid QT-prolonging meds when possible.🚑 If TdP develops: Defibrillate + IV magnesium and stop offending agents. Click here for Direct Download of the Podcast. 📝 Introduction The QT interval is a vital part of ECG interpretation, reflecting the heart’s electrical recovery after each beat. When prolonged, it can set