Clinical Liver Disease

Cystic fibrosis affects nearly 1 in every 3000 live births, and is the most common fatal autosomal recessive disease among Caucasians. There's a wide spectrum of liver disease among CF patients, from steatosis, to cirrhosis, and severe portal hypertension.

Review the clinical characteristics, liver biochemistry, and the range of complications that can present in biliary atresia; as well as the recommended treatments and follow-up..

While PSC is a relatively rare cholangiopathy that presents more commonly in the Caucasion male population, LT is the only therapy that can reverse or correct resulting end-stage liver disease.

Improvements in medical and surgical care mean that more and more children with inherited cholestatic disorders can expect to survive into adulthood and require care by adult hepatologists.

Learn about the pros and cons of transition versus transfer, the challenges of nonadherence, determining readiness to transfer care, and other considerations important in planning for successful long-term outcomes.

The Fontan operation establishes independent pulmonary and systemic circulations in patients with a single functional ventrical, and is the most common congenital heart disease procedure after 2 years of age.

Audible Article by Niharika Samala and Marc G. Ghany

Audible Article by Heiner Wedemeyer, Svenja Hardtke and Michael P. Manns

Audible Article by Charles Phan and F. Blaine Hollinger

Audible Article by Raffaella Romeo

Audible Article by Rakesh Aggarwal

Audible Article by Noele P. Nelson and Trudy V. Murphy

Audible Article by Albert J. Czaja

Audible Article by Giorgina Mieli-Vergani and Diego Vergani

Audible Article by Michael Ronan Lucey

Audible Article by Michael R. Lucey and John M. Vierling

Audible Article by Meredith Borman and Mark G. Swain

Audible Article by Michael P. Manns and Richard Taubert

Liver allograft biopsy is crucial to the posttransplant management of patients treated for end-stage chronic liver disease, ALF, or HCC. Markers of graft injury such as parenchymal and biliary injury can be useful, but aren't specific, and enzyme changes may lack sensitivity in the context of transplantation.

HCV infection universally recurs in patients who are viremic at the time of transplantation, leading to reduced graft survival and increased patient mortality. Review the current interferon-based therapies and learn about emerging drugs and interferon-free treatment from experts Dr. Asmeen Bhatt and Dr. Gregory Everson.